Targeted Deep Sequencing Reveals No Definitive Evidence for Somatic Mosaicism in Atrial Fibrillation Running title: Roberts et al.; Somatic Mosaicism and Atrial Fibrillation

Targeted Deep Sequencing Reveals No Evidence for Somatic Mosaicism in Atrial Fibrillation Running title: Roberts et al.; Somatic Mosaicism and Atrial Fibrillation

Targeted deep sequencing reveals no definitive evidence for somatic mosaicism in atrial fibrillation.

BACKGROUND Studies of ≤15 atrial fibrillation (AF) patients have identified atrial-specific mutations within connexin genes, suggesting that somatic mutations may account for sporadic cases of the arrhythmia. We sought to identify atrial somatic mutations among patients with and without AF using targeted deep next-generation sequencing of 560 genes, including genetic culprits implicated in AF, ...

Paradigm of genetic mosaicism and lone atrial fibrillation: physiological characterization of a connexin 43-deletion mutant identified from atrial tissue.

BACKGROUND Atrial fibrillation (AF) is the most common sustained arrhythmia observed in otherwise healthy individuals. Most lone AF cases are nonfamilial, leading to the assumption that a primary genetic origin is unlikely. In this study, we provide data supporting a novel paradigm that atrial tissue-specific genetic defects may be associated with sporadic cases of lone AF. METHODS AND RESULT...

Atrial Fibrillation and Stroke Prevention in Aging Patients: What’s Good Can be Even Better Running title: Freedman et al.; Atrial Fibrillation, Stroke and Aging

Mass Screening for Untreated Atrial Fibrillation: The STROKESTOP Study Running title: Svennberg et al.; Mass Screening for Untreated Atrial Fibrillation

Background—The aim of the present study was to define the prevalence of untreated atrial